The Tri-State STEM+M Early College High School was conceptualized through a shared vision among the region’s business community, major employers, workforce development organizations, civic and government agencies, nonprofit organizations, and institutions of higher education. The founding partners’ committed efforts resulted in new public STEM school charter being granted by the state of Ohio in the summer of 2015 to the founding Chief Executive Officer, Dr. C. Scott Howard. Tri-State STEM+M Early College High School, located at 702 Solida Road, South Point, Ohio. Tri-State STEM+M opened in the fall of 2017 with a focus on science, technology, engineering, mathematics, and medicine – as the medical field is the largest employer in the Tri-State region. The school design team intentionally connected community stakeholders with learners, faculty, and staff who will collectively identify concepts of health, wellness, medical treatment, and sustainable change that will initiate personal engagement and promote student agency. Currently, in its second school year, Tri-State STEM+M provides fully accredited high school credits and College Credit Plus (dual enrollment) courses to 65 students in 9-11th grade from Ohio, West Virginia, and Kentucky.